This graduate-level course explores the theoretical and scientific foundations of nursing with a focus on advancing quality and safety in healthcare. Grounded in patient-centered care, students will examine how nursing science informs evidence-based practice, clinical inquiry, and innovation. Emphasis is placed on the integration of interdisciplinary collaboration, leadership theory, and systems thinking to address complex healthcare challenges. Students will critically analyze current research, quality improvement models, and data-driven strategies to lead transformative change in healthcare delivery. Through a quality-focused lens, learners will develop skills to champion high-value, equitable care across diverse settings.